The crash happened near 2600 West Old Highway Road.
Five friends were riding in a ranger when they took a corner too quickly and lost control of the vehicle.
All find teens were ejected from the vehicle.
A 13-year-old boy and 14-year-old girl were taken to Primary Children’s Hospital in critical condition.
A 13-year-old girl and a 13-year-old boy were taken to McKay Dee Hospital by ambulance with non-life threatening injures, but in serious condition.
The fifth teen in the vehicle was not transported to the hospital.