The video begins with Owen Wilson talking to actor Harry Dean Stanton about making it as an actor. The conversation is less about acting advice and more about the meaning of life.
Shortly after the song begins an animated version of Wilson guides us through the lyrics and the feeling of the song as he watches himself surrounding by people, but feeling all alone. Killers lead vocalist Brandon Flowers sounds pained or wounded or heartbroken as sings the lyrics. The song comes to an end by moving into a version of White Christmas.
The proceeds of the song benefit the Global Fund to Fight AIDS.