Three people have been transported to the hospital in unknown condition.
The driver of the semi walked away for the accident unharmed.
Hazmat was called in to clean up what was estimated to be 150 gallons of diesel fuel.
The accident caused a road closure to traffic in both directions.
Emergency teams are still on site and traffic flow will be returned to normal as soon as possible.
Stay tuned to ABC 4 News and abc4.com for updates.
Copyright 2016 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.