UHP troopers say the semi was traveling eastbound on SR-20 at about milepost 11 near Panguitch in Iron County.
Troopers say it appears the driver was traveling too fast around a curve and lost control of the vehicle, which rolled onto its right side and hit a guardrail.
The semi caught fire and the cab became fully engulfed and the driver, who was the only occupant died on scene from injuries and burns.
The trailer was loaded with Ice Cream that was heading to an unknown location. Lane closures were in place for about 1 hour.
It is also unknown at this point if the driver was wearing a seatbelt.
The victim was later identified as Janine M. Koons From Stage Coach, Nevada.
----Information from: Utah Highway Patrol